Medical experts have unveiled a new breakthrough that could change how doctors detect heart disease.
According to a new global research study published in Circulation, scientists have discovered that a simple blood test could accurately predict whether someone is likely to suffer from a heart attack or other serious heart problems—long before any visible symptoms appear.
The study tracked more than 10,000 people from diverse racial, cultural, and age groups across the world. Researchers focused on over 100 epigenetic markers in the blood to see how tiny changes in DNA could reveal a person’s long-term heart health.
These changes, known as DNA methylation, work like chemical “tags” that can switch genes on or off. What makes them more fascinating is that they are heavily influenced by lifestyle choices such as diet, exercise, smoking, stress, and even sleep quality.
Instead of waiting for patients to develop severe symptoms—or relying only on costly hospital machines—doctors could soon analyse simple blood samples to detect risks earlier.
The researchers discovered more than 600 methylation markers linked to heart health. Of these, 141 stood out as being strongly associated with major cardiovascular problems like strokes, heart failure, and even conditions like high blood pressure during pregnancy.
What shocked researchers is how reliable these blood markers were even without including traditional risk checks such as cholesterol levels or blood pressure readings.
People with healthier methylation patterns were found to have 32% lower chances of developing heart disease, regardless of their usual medical test results.
The scientists also created a lifestyle scoring system that combined important health factors like body weight, sugar levels, cholesterol, smoking and drinking habits, physical activity, and sleep quality.
Unsurprisingly, people who scored higher for healthy living also had more “favourable” DNA profiles, showing a clear link between lifestyle and genetic health.
Co-author Dr. Zheng explained that the study was designed to answer two key questions: whether these heart-related DNA markers were consistent across different races, genders, and age groups, and whether they could serve as reliable early-warning signs beyond the standard risk factors used in hospitals today.
The findings confirmed both assumptions.
Even more encouraging, those with favourable DNA changes were not just less likely to develop heart disease—they were 40% less likely to die from it and 45% less likely to pass away from any heart-related cause.
The most promising aspect of the study is that DNA methylation is not fixed. Scientists believe that lifestyle improvements—such as better diet, exercise, or quitting smoking—could actually reverse risky DNA markers.
If proven, this means that the test could not only predict problems but also guide patients on what lifestyle changes to make in order to dramatically improve their chances of avoiding heart emergencies.
The research team is now collaborating with health companies to develop affordable, easy-to-use blood test kits that can be distributed to clinics and hospitals worldwide.
Such tools would be especially valuable in countries like Kenya, where most people rarely go for routine heart check-ups and often discover heart disease only when it is too late.
If rolled out widely, this test could become one of the most powerful tools in preventive medicine—helping doctors catch heart risks early, saving countless lives, and encouraging people to live healthier, more heart-conscious lifestyles.
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